Enalaprilat and enalapril maleate eyedrops lower intraocular pressure in rabbits
نویسندگان
چکیده
منابع مشابه
Effect of Calcium Channel Blockers on Intraocular Pressure in Rabbits
The objective of the study was to evaluate the antiglaucoma effect of calcium channel blockers diltiazem and verapamil. Albino rabbits were used and chronic glaucoma was induced in them using freshly prepared 150 units of alphachymotrypsin. 0.1 mL of drug solution was administered topically into the left eye whereas the right served as control. The pressure recording was carried out at 15, 30, ...
متن کاملPharmacokinetics and pharmacodynamics profiles of enalapril maleate in healthy volunteers following determination of enalapril and enalaprilat by two specific enzyme immunoassays.
BACKGROUND AND OBJECTIVES Most of the pharmacokinetic (PK) parameters for enalapril and enalaprilat were established following determination of the drug and its metabolite, using angiotensin converting enzyme (ACE) inhibition assays. In these methods, enalapril has to be hydrolysed to enalaprilat first and then assayed. The purpose of this study was to re-estimate the PK parameters of enalapril...
متن کاملHydroxyamphetamine increases intraocular pressure in rabbits.
OBJECTIVE To determine the effect of norepinephrine (NE) released from endogenous ocular stores on intraocular pressure (IOP) and aqueous flow in rabbits. METHODS The IOP was measured with a pneumatonometer, the aqueous flow with a scanning fluorophotometer, and the aqueous NE by methylation with catechol-O-methyltransferase in the presence of S-adenosyl-L-[methyl-(3)H]methionine. RESULTS H...
متن کاملEffects of latanoprost and pilocarpine combination on the intraocular pressure and pupil size of normal rabbits
The aim of this study was to determine the combination effect of latanoprost and pilocarpine on theintraocular pressure and pupil size in normal rabbits. In this study, 18 rabbits were randomized to threegroups of 6 animals each. The right eyes of rabbits in group 1 were treated topically with latanoprost, ingroup 2 with pilocarpine and in group 3 with latanoprost and pilocarpine. The left eyes...
متن کاملEffects of concomitant administration of latanoprost and pilocarpine on the intraocular pressure of experimentally glaucomatous rabbits
The purpose of this study was to evaluate the effects of a combination of latanoprost and pilocarpine onthe intraocular pressure in experimentally glaucomatous rabbits. Ocular hypertension was induced in 11conscious rabbits by the oral administration of tap water (70 mL/kg) via an orogastric tube. The study wasconducted in three therapeutic groups to test the effects of latanoprost (group L), p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Ophthalmologica
سال: 2009
ISSN: 1755-375X,1755-3768
DOI: 10.1111/j.1755-3768.2008.01495.x